Novel engraftment and T cell differentiation of human hematopoietic cells in Art-/- IL2RG-/ SCID pigs
A. Boettcher, Y. Li, A. Ahrens, M. Kiupel, K. Byrne, C. Loving, A. G. Cino-Ozuna, J. Wiarda, M. Adur, B. Schultz, J. Swanson, E. Snella, C.-S. Ho, S. Charley, Z. Kiefer, , C. Tuggle
The paper generates a T-B-NK-SCID pig model via CRISPR/Cas9 and demonstrates successful human hematopoietic cell engraftment in blood and lymphoid organs after in utero injection.
bioRxiv · May 2, 2019 · PreprintImmunology