Combined Inhibition of AKT and KIT Restores Expression of Programmed Cell Death 4 (PDCD4) in Gastrointestinal Stromal Tumor
M. Kozinova, S. Joshi, S. Ye, M. G. Belinsky, D. Sharipova, J. M. Farma, S. Reddy, S. Litwin, K. Devarajan, A. R. Campos, Y. Yu, B. Schwartz, M. von Mehren, L. Rink
This study shows that combining AKT and KIT inhibitors restores PDCD4 expression in GIST cells, leading to cell death, but the combination is less effective in IM-resistant models.
bioRxiv · Apr 13, 2021Cancer Biology