S. Joshi

Effects of Bimodal Olfactory and Mechanosensory Inputs in the Antennal Lobe of the Honeybee Apis mellifera

This paper shows that olfactory and mechanosensory signals integrate in the honeybee antennal lobe, supporting early multisensory processing in insects.

Determining Optimal Placement of Copy Number Aberration Impacted Single Nucleotide Variants in a Tumor Progression History

This paper introduces DETOPT, a method for accurately placing SNVs affected by CNAs in tumor progression trees, showing improved accuracy on simulated data and biologically plausible results on breast cancer metastases.

DCs targeted therapy expands CD8 T cell responses to bona-fide neoantigens in lung tumors

The paper shows that DC-based therapy enhances CD8 T cell responses to neoantigens in lung tumors, particularly in high TMB tumors.

Three-dimensional assessments are necessary to determine the true, spatially-resolved composition of tissues

This study shows that 3D assessments are necessary to accurately determine tissue composition and neoplastic content, as 2D methods under-sample spatial heterogeneity.

ALCAM-mediated synapses between DC1 and CD8 T cells are inhibited in advanced lung tumors

The paper shows that ALCAM-mediated synapses between DC1 and CD8 T cells decrease in advanced lung tumors, impairing immune responses.

Tim4 enables large peritoneal macrophages to cross-present tumor antigens at early stages of tumorigenesis

This study shows TIM4 enables large peritoneal macrophages to cross-present tumor antigens early in tumorigenesis, promoting CD8 T cell activation and immune surveillance.

Platelet-Localized ST6Gal1 Does Not Impact IgG Sialylation

This study investigates whether platelet-localized ST6Gal1 affects IgG sialylation and finds no significant impact.

A new microphysiological system shows hypoxia primes human ISCs for interleukin-dependent rescue of stem cell activity

This study uses a microphysiological system to show hypoxia primes human intestinal stem cells (hISCs) to respond to interleukins, enhancing their activity under hypoxic conditions.

Broad-spectrum antiviral inhibitors targeting pandemic potential RNA viruses

This study identifies broad-spectrum antiviral agents effective against multiple RNA virus families, including arboviruses and respiratory pathogens.

CineFinch: An animated female zebra finch for studying courtship interactions

The paper develops an animated female zebra finch to study courtship interactions and finds that 40% of male zebra finches sing to the animation.

Impaired hepatic autophagy exacerbates xenobiotics induced liver injury

This study shows that impaired hepatic autophagy worsens xenobiotic-induced cholestatic liver injury by promoting p62-Ub-IHB accumulation and suppressing FXR.

Multi-modal Imaging of Disease Progression in TH-MYCN Mouse Models of Neuroblastoma

This study uses multi-modal imaging to compare tumor progression and vascular architecture in TH-MYCN transgenic and implanted neuroblastoma models.

SOL3D: Soft-lithography on 3D vat polymerised moulds for fast, versatile, and accessible high-resolution fabrication of customised multiscale cell culture devices with complex designs

This paper introduces a low-cost, high-resolution method for fabricating custom cell culture devices using 3D printing and PDMS soft lithography, enabling widespread use in biological labs.

ECS1 and ECS2 regulate polyspermy and suppress the formation of haploid plants by promoting double fertilization

This paper shows that ECS1 and ECS2 promote double fertilization and prevent haploid and triploid plant formation by regulating pollen tube block and synergid disintegration.

Characterization of metabolic compartmentalization in the liver using spatially resolved metabolomics

This study uses spatially resolved metabolomics to characterize metabolic compartmentalization in the liver and shows how nutrient stress disrupts this organization.

A versatile mitochondria isolation- and analysis-pipeline generates 3D nano-topographies and mechano-physical surface maps of single organelles

This paper introduces a pipeline for isolating and analyzing single mitochondria to generate 3D nano-topographies and mechano-physical surface maps, revealing diversity in mitochondrial properties.

Differential analysis of pesticides biodegradation in soil using conventional and high-throughput technology

The paper identifies a bacterial isolate capable of degrading multiple pesticides and shows its potential for bioremediation in contaminated soil.

Combined Inhibition of AKT and KIT Restores Expression of Programmed Cell Death 4 (PDCD4) in Gastrointestinal Stromal Tumor

This study shows that combining AKT and KIT inhibitors restores PDCD4 expression in GIST cells, leading to cell death, but the combination is less effective in IM-resistant models.

Immunoreactive peptide maps of SARS-CoV-2 and other human coronaviruses

The paper identifies humoral immune responses to SARS-CoV-2 and other human coronaviruses peptides to detect infections and discover immunity biomarkers.

Calcium ion chelation preserves platelet function during cold storage

This study identifies integrin activation and apoptosis as the mechanism of rapid platelet clearance after cold storage and shows that EGTA treatment enables cold storage of platelets for transfusion.

Kinetics characterization of ASXL1/2-mediated allosteric regulation of BAP1 deubiquitinase

This study characterizes the kinetics and stoichiometry of BAP1 and ASXL2 interactions, revealing their structural and functional properties in deubiquitinase activity.

Correlates of non-random patterns of capsule switching in pneumococcus

The paper identifies serotype pairs in pneumococcus that co-occur more frequently on genetic lineages and links these patterns to shared polysaccharide components.

Growth characteristics of pneumococcus vary with the chemical composition of the capsule and with environmental conditions

The paper examines how pneumococcus growth varies with environmental conditions and capsule composition, finding associations between growth characteristics and serotype prevalence.

Formulation, Evaluation and Antibacterial Efficiency of water-based herbal Hand Sanitizer Gel

This study evaluates the antibacterial efficacy of herbal oils and a poly-herbal hand wash gel, finding cinnamon oil and the formulated gel effective against bacterial pathogens.