S. Ye

Spiking and locus coeruleus input drive predictive visuomotor plasticity in V1 layer 2/3 neurons

The paper shows that spiking in layer 2/3 neurons and locus coeruleus axons drive visuomotor plasticity in mouse V1, supporting prediction error minimization through activity-dependent reorganization.

Mass Generation and Long-term Expansion of Hepatobiliary Organoids from Adult Primary Human Hepatocytes

This study develops a method to generate and expand hepatobiliary organoids from adult human hepatocytes, which retain liver function and can model liver diseases.

Exogenous myristate fuels the growth of symbiotic arbuscular mycorrhizal fungi but disrupts their carbon-phosphorus exchange with host plants

This study shows that exogenous myristate supports AMF growth but reduces phosphorus transfer to host plants, suggesting it may hinder symbiosis.

Novel Imaging Guidance for Cholesteatoma Surgery usingTissue Autofluorescence

The paper develops a fluorescence imaging system to distinguish cholesteatoma tissue from middle ear mucosa using autofluorescence properties during surgery.

A Novel Angiogenesis Role of GLP-1(32-36) to Rescue Diabetic Ischemic Lower Limbs via GLP-1R-Dependent Glycolysis

This study identifies GLP-1(32-36) as a therapeutic agent that rescues diabetic ischemic lower limbs by enhancing glycolysis and EPC function via GLP-1R-dependent mechanisms.

Computational insights into the conformational transition of STING: mechanistic, energetic considerations, and the influence of crucial mutations

This study investigates the conformational transition of STING upon cGAMP binding, identifying mutations that affect the energetic landscape and suggesting V147L may not be a gain-of-function mutation.

Micropolarity governs the structural organization of biomolecular condensates

The paper shows that micropolarity differences between subcompartments dictate the structural organization of biomolecular condensates, leading to layered structures and functional changes.

Microphase Separation Produces Interfacial Environment within Diblock Biomolecular Condensates

This study uses simulations and experiments to show that diblock polypeptides form interfacial environments due to hydrophilic-hydrophobic residue distribution, affecting condensate stability and hydrogen bonding.

Probing the hierarchical dynamics of DNA-sperm nuclear transition protein complex through fuzzy interaction and mesoscale condensation

This study investigates the hierarchical dynamics of TNP1-DNA interactions using computational and experimental methods to understand DNA condensation and its implications for vaccine design.

Cryo-EM structure of the polyphosphate polymerase VTC: Coupling polymer synthesis to membrane transit

The paper determines the cryo-EM structure of the yeast VTC complex, revealing its architecture and mechanism for polyphosphate synthesis and translocation across the vacuolar membrane.

High-resolution small RNAs landscape provides insights into alkane adaptation in the marine alkane-degrader Alcanivorax dieselolei B-5

This study identifies sRNA candidates in Alcanivorax dieselolei B-5 under alkane and non-alkane conditions, revealing their roles in alkane metabolism and adaptation.

A self-blinking DNA probe for 3D superresolution imaging of native chromatin

This paper introduces a self-blinking DNA probe for 3D superresolution imaging of native chromatin in live cells, revealing chromatin organization and decompaction dynamics.

Imaging the Extent and Location of Spatiotemporally Distributed Epileptiform Sources from MEG Measurements

This study applies the FAST-IRES algorithm to MEG data to image the location and extent of epileptiform sources in drug-resistant epilepsy patients.

An atlas of human viruses provides new insights into diversity and tissue tropism of human viruses

The paper curates an atlas of human viruses, revealing increased diversity in infants and factors influencing tissue tropism, while introducing the Human Virus Database.

Chlamydomonas State Transition Is Quiet Around Pyrenoid and Independent from Thylakoid Deformation

The paper investigates state transition in Chlamydomonas, finding reduced ST activity near the pyrenoid and structural changes independent of LHCII phosphorylation.

Short-term instantaneous prophylaxis and efficient treatment against SARS-CoV-2 in hACE2 mice conferred by an intranasal nanobody (Nb22)

This paper demonstrates that intranasal nanobody Nb22 provides short-term instantaneous prophylaxis and effective treatment against SARS-CoV-2 in hACE2 mice, with ultrahigh potency and long-lasting retention in the respiratory system.

OsciDrop: A versatile on-demand droplet generator

OsciDrop generates size-tunable, monodisperse droplets on demand without microfabrication, enabling chip-free droplet assays for applications like virus quantification.

Multi-animal pose estimation and tracking with DeepLabCut

The paper enhances DeepLabCut for multi-animal pose estimation and tracking by adding identity prediction and robust assembly features, validated on four benchmark datasets.

Combined Inhibition of AKT and KIT Restores Expression of Programmed Cell Death 4 (PDCD4) in Gastrointestinal Stromal Tumor

This study shows that combining AKT and KIT inhibitors restores PDCD4 expression in GIST cells, leading to cell death, but the combination is less effective in IM-resistant models.

Proinflammatory and autoimmunogenic gut microbiome in systemic lupus erythematosus

The paper identifies proinflammatory gut microbiome features in SLE patients through metagenomic analysis and shows potential autoimmunogenic mechanisms.

Auxin guides germ cell specification in Arabidopsis anthers

This study shows auxin guides germ cell specification in Arabidopsis anthers by creating a centripetal gradient that is essential for GC initiation and patterning.

An agent-based model of adaptation of holobionts with different microbial symbiont transmission modes

This paper uses an agent-based model to show that holobionts with horizontal microbial symbiont transmission can adapt to increasing abiotic stress through symbiont adaptation, depending on host-symbiont recognition abilities.

Effects of N, P, K on Yield and Quality of Jujube in the Loess Hilly Region and Its Fertilization Model

This study identifies the optimal N, P, K fertilization model for jujube in the Loess Hilly Region, showing that N1P3K3 maximizes yield and specific quality traits.

Identification of Wee1 as Target in Combination with Avapritinib for the Treatment of Gastrointestinal Stromal Tumors

This study identifies Wee1 as a therapeutic target in combination with avapritinib for treating gastrointestinal stromal tumors (GIST) by analyzing kinome profiles and conducting functional assays.

Id proteins promote a cancer stem cell phenotype in triple negative breast cancer via negative regulation of Robo1

This study shows that Id proteins promote a cancer stem cell phenotype in triple negative breast cancer by negatively regulating Robo1, leading to Myc activation.

Microbial Communities Associated with Sustained Anaerobic Reductive Dechlorination of α-, β-, γ-, and δ-Hexachlorocyclohexane Isomers to Monochlorobenzene and Benzene

This study compares anaerobic microbial communities involved in dechlorinating different HCH isomers, identifying key bacteria and revealing shifts in community composition based on substrate.

The methyl cycle is a conserved regulator of biological clocks.

This study shows the methyl cycle regulates circadian and somite segmentation clocks across species, highlighting its role as a conserved metabolic regulator of biological clocks.

Deep sequencing of primary human lung epithelial cells challenged with H5N1 influenza virus reveals a proviral role for CEACAM1

The paper uses deep sequencing to show that CEACAM1 is upregulated in H5N1-infected lung cells and its silencing reduces viral replication and inflammation.

Species composition and environmental adaptation of indigenous Chinese cattle

The paper analyzes genetic diversity and adaptation in indigenous Chinese cattle, identifying genes associated with environmental adaptation and confirming historical admixture patterns.