Novel heme-binding enables allosteric modulation in an ancient TIM-barrel glycosidase
G. Gamiz-Arco, L. Gutierrez-Rus, V. Risso, B. Ibarra-Molero, Y. Hoshino, D. Petrovic, A. Romero-Rivera, B. Seelig, J. Gavira, S. Kamerlin, E. Gaucher, J. Sanchez-Ruiz
This study identifies a heme-binding site in an ancestral glycosidase, showing how heme binding rigidifies the TIM-barrel and enhances catalysis.
bioRxiv · May 27, 2020Biophysics