Injectable diblock copolypeptide hydrogel provides platform to maintain high local concentrations of taxol and local tumor control
M. Garrett, A. L. Wollenberg, A. M. Bernstein, T. M. OShea, D. Hung, B. Staarman, H. Soto, T. J. Deming, M. V. Sofroniew, H. I. Kornblum
This paper develops an injectable hydrogel to deliver paclitaxel for glioblastoma treatment, achieving high local concentrations and improved survival in mice, but tumor cells can still escape the treatment area.
bioRxiv · Jul 1, 2019Cancer Biology