Deep sequencing of the T cell Receptor reveals common and reproducible CD8+ signatures of response to checkpoint immunotherapy
R. A. Watson, C. Taylor, O. Tong, R. A. Cooper, E. Jungkurth, P. Kumar Sharma, B. Storey, W. Ye, B. Sun, A. de los Aires, F. Matos Santo, I. Nassiri, J. Gilchrist, E. Ieremia, M. R. Middleton, B. P. Fairfax
The paper uses TCR sequencing to identify CD8+ T cell clones associated with response to checkpoint immunotherapy in metastatic melanoma, finding a correlation between peripheral ER clone proportion and clinical outcome.
bioRxiv · Feb 11, 2023 · PreprintImmunology