B. Sun

SKP2-mediated FBXO2 proteasomal degradation drives hepatocellular carcinoma progression via stabilizing Hsp47

The paper shows that loss of FBXO2 promotes hepatocellular carcinoma by stabilizing Hsp47 through SKP2-mediated proteasomal degradation.

Single-Molecule Orientation Imaging Reveals the Nano-Architecture of Amyloid Fibrils Undergoing Growth and Decay

This study uses SMOLM to analyze A{beta}42 fibril architecture and dynamics, finding that order and heterogeneity correlate with growth and decay.

Granzyme B-based CAR T cells block metastasis by eliminating circulating tumor cells

This study develops GrB-CAR T cells targeting mHSP70 to eliminate CTCs and inhibit metastasis in solid tumors.

Balance Between EGF/STAT1 and IFNγ/NRF2 Signaling Controls ECM1 Expression and Determines Hepatic Homeostasis versus Chronic Liver Disease

This study identifies EGF/STAT1 and IFNγ/NRF2 signaling pathways regulating ECM1 expression, showing their role in maintaining liver homeostasis versus promoting chronic liver disease.

ECM1 Attenuates Hepatic Fibrosis by Interfering with Mediators of Latent TGF-β1 Activation

This study shows ECM1 prevents hepatic fibrosis by inhibiting TGF-β1 activation, with implications for developing safe anti-fibrotic therapies.

Lithocholic acid targets TULP3 to activate sirtuins and AMPK to retard ageing

This study identifies LCA's mechanism of action through TULP3-sirtuin-v-ATPase-AMPK pathway to activate AMPK and extend lifespan in model organisms.

Behavioral adaptation to changing energy constraints via altered frequency of movement selection

The paper shows larval zebrafish adjust movement frequency to minimize energy use as they grow, even in altered fluid environments.

Specificity and promiscuity of JAK recruitment regulates pleiotropy of cytokine-receptor signaling

The paper investigates JAK recruitment specificity and promiscuity in cytokine-receptor signaling, finding that JAKs can interchangeably bind to receptors, leading to cell type-specific signaling pleiotropy.

A telomere-to-telomere genome assembly of Zhonghuang 13, a widely-grown soybean variety from the original center of Glycine max

This paper presents the first telomere-to-telomere genome assembly of the soybean cultivar Zhonghuang 13, resolving gaps and identifying novel genes and structural variations.

Reconciling ASPP-p53 Binding Mode Discrepancies through an Ensemble Binding Framework that Bridges Crystallography and NMR Data

This study reconciles discrepancies in ASPP-p53 binding modes by showing that an ensemble of simulated complexes better aligns with experimental data than single crystal structures.

Single-cell immune multi-omics and repertoire analyses in pancreatic ductal adenocarcinoma reveal differential immunosuppressive mechanisms within different tumour microenvironments

The paper analyzes single-cell immune multi-omics data from PDAC to identify differential immunosuppressive mechanisms in distinct tumour microenvironments.

Alternative splicing of a potato disease resistance gene maintains homeostasis between development and immunity

The paper shows that the potato resistance gene RB uses alternative splicing to balance growth and immunity, with the pathogen effector IPI-O1 promoting splicing to enhance immunity.

Deep sequencing of the T cell Receptor reveals common and reproducible CD8+ signatures of response to checkpoint immunotherapy

The paper uses TCR sequencing to identify CD8+ T cell clones associated with response to checkpoint immunotherapy in metastatic melanoma, finding a correlation between peripheral ER clone proportion and clinical outcome.

Genomic Analysis of Blomia tropicalis Identifies Novel Allergens for Component-Resolved Diagnosis of Mite Allergy

This study identifies a comprehensive allergen profile of Blomia tropicalis and validates novel allergens for component-resolved diagnosis of mite allergy.

3D co-culture of macrophages and fibroblasts in a sessile drop chip for unveiling the role of macrophages in skin wound-healing

This study develops a sessile drop chip to create 3D spheroids of fibroblasts and macrophages, showing that M2 macrophages enhance fibroblast proliferation and differentiation in a wound-healing model.

Multi-Omic Analysis of Tyrophagus putrescentiae Reveals Insights into the Allergen Complexity of Storage Mites

This study reveals a comprehensive allergen profile of Tyrophagus putrescentiae using multi-omic approaches, identifying 37 allergen groups and five novel allergens.

An R-R-type MYB transcription factor promotes nonclimacteric pepper fruit ripening pigmentation

This study identifies a MYB transcription factor that regulates capsanthin biosynthesis in nonclimacteric pepper fruit, showing its role in carotenoid accumulation and interaction with abscisic acid.

TLR4/NF-κB Signaling Contributes to the Inflammation in Ovary and Inguinal Fats of Polycystic Ovary Syndrome

This study shows that TLR4/NF-κB signaling increases inflammation in ovarian and inguinal fat tissues of PCOS rats, worsening metabolic and reproductive symptoms.

Collagen remodeling dictates pancreatic cancer bioenergetics and outcome through DDR1 activation or degradation

This study shows that collagen remodeling via MMP cleavage affects pancreatic cancer bioenergetics and outcome through DDR1 activation or degradation, with distinct impacts on tumor growth and survival.

Neuronal miR-138 represses HSV-2 lytic infection by regulating viral and host genes with mechanistic differences compared to HSV-1

This study shows miR-138 suppresses HSV-2 lytic infection by targeting viral and host genes, with distinct mechanisms compared to HSV-1.

The m6A writer FIONA1 methylates the 3'UTR of FLC and controls flowering in Arabidopsis

The paper identifies FIONA1 as an m6A methyltransferase that methylates the 3'UTR of FLC, stabilizing its mRNA and controlling flowering in Arabidopsis.

The Flowering Repressor SVP recruits the TOPLESS co-repressor to control flowering in chrysanthemum and Arabidopsis

This study shows that SVP interacts with TPL to repress flowering by inhibiting FT gene expression in chrysanthemum and Arabidopsis, highlighting a conserved mechanism across species.

Three-dimensional Cancer Cell Migration Directed by Dual Mechanochemical Guidance

This study investigates how breast cancer cells migrate in 3D under dual mechanochemical guidance, finding that ECM alignment and chemotactic gradients interact to influence migration efficiency.

Correlation analysis among single nucleotide polymorphisms in thirteen language genes and culture/education parameters from twenty-six countries

This study examines correlations between SNPs in 13 language genes and culture/education parameters across 26 countries using PCA.

Comparative genomic and pan-genomic characteristion of Staphylococcus epidermidis from different sources unveils the molecular basis and potential biomarkers of pathogenic strains

This study sequenced and analyzed 11 ocular trauma-sourced S. epidermidis genomes, identifying 10 potential biomarkers and revealing pathogenic strains may be independent of biofilm formation.

Systematic analysis of the R2R3-MYB family of transcription factors in Camellia sinensis: evidence for species-specific catechin biosynthesis regulation

This study identifies R2R3-MYB transcription factors in C. sinensis and links some to the regulation of galloylated catechin biosynthesis.

Previously unrecognized non-reproducible antibody-antigen interactions and their implications for diagnosis of viral infections including COVID-19

The paper identifies non-reproducible antibody-antigen interactions in clinical sera and develops a model to explain them, improving serological testing for viral infections like COVID-19.

The noncoding RNA PRANCR regulates splicing of Fibronectin-1 to control keratinocyte proliferation and migration

This study identifies PRANCR as a lncRNA that regulates alternative splicing of FN1 to control keratinocyte proliferation and migration.

Purinoreceptors and ectonucleotidases control ATP-induced calcium waveforms and calcium-dependent responses in microglia

This study uses computational modeling to show that purinoreceptors and ectonucleotidases regulate ATP-induced calcium waveforms and microglia responses, with different waveforms driving distinct functional outcomes.

The non-canonical interaction between calmodulin and calcineurin contributes to the differential regulation of plant-derived calmodulins on calcineurin.

This study investigates how plant-derived calmodulin variants differentially regulate calcineurin through non-canonical interactions beyond calcium binding and canonical CaMBR binding.