Sustained hyperglycemia specifically targets translation of mRNAs for insulin secretion
A. Cheruiyot, J. Hollister-Lock, B. Sullivan, H. Pan, J. M. Dreyfuss, S. Bonner-Weir, J. E. Schaffer
This study shows that sustained high glucose reduces translation of mRNAs involved in insulin secretion in beta-cells, impairing their function.
bioRxiv · Sep 29, 2023Cell Biology