Replication-driven HBV cccDNA loss in chimeric mice with humanized livers
B.-H. Zhang, Y. Zhou, B. Tempel, H. Pan, S. Horrigan, L. Luckenbaugh, F. Zoulim, J. Hu, Y.-Y. Zhang
This study shows that replication-driven cccDNA loss occurs in HBV-infected chimeric mice with humanized livers, and blocking cccDNA replenishment pathways significantly reduces cccDNA levels.
bioRxiv · Dec 28, 2023Microbiology