Distinct pathogenic influence of anti-HMGCR+ and anti-SRP+ immune-mediated necrotizing myopathy autoantibodies on engineered muscle function
Heta Lad, Yekaterina Tiper, Ernest Myguel Esteban, Manish Kumar Singh, Alexandrine Mahoudeau, Zhuoye Xie, B. Tendrel, Yves Allenbach, Olivier Benvéniste, Penney M. Gilbert
This study shows that anti-HMGCR and anti-SRP autoantibodies from IMNM patients have distinct direct effects on engineered muscle function, with anti-HMGCR reducing contractile force and anti-SRP causing atrophy without affecting force.
Skeletal Muscle · Nov 25, 2025Peer-reviewedBioengineering