Author

Heta Lad

University of Toronto

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Penney M. GilbertiD· 2 shared Alexandrine MahoudeauiD· 1 shared B. Tendrel· 1 shared Claúdia C. dos SantosiD· 1 shared Craig A. SimmonsiD· 1 shared D. AdaoiD· 1 shared Ernest Myguel Esteban· 1 shared Filio BilliaiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersBioengineering

Penney M. GilbertORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Transcriptomic analysis of human induced pluripotent stem cell cardiomyocytes and myocardial tissue reveals novel role for miR-9-5p in hypertrophic cardiomyopathy

D. Adao, Heta Lad, Mingyi Tang, Sophia G Lopez, Filio Billia, Craig A. Simmons

This study identifies miR-9-5p as a regulator of cardiomyocyte hypertrophy and contractility in HCM using iPSC models and miRNA profiling.

bioRxiv · Sep 13, 2026 · PreprintMolecular Biology

Distinct pathogenic influence of anti-HMGCR+ and anti-SRP+ immune-mediated necrotizing myopathy autoantibodies on engineered muscle function

Heta Lad, Yekaterina Tiper, Ernest Myguel Esteban, Manish Kumar Singh, Alexandrine Mahoudeau, Zhuoye Xie, B. Tendrel, Yves Allenbach, Olivier Benvéniste, Penney M. Gilbert

This study shows that anti-HMGCR and anti-SRP autoantibodies from IMNM patients have distinct direct effects on engineered muscle function, with anti-HMGCR reducing contractile force and anti-SRP causing atrophy without affecting force.

Skeletal Muscle · Nov 25, 2025Peer-reviewedBioengineering

Clinical risk factors of intensive care unit acquired weakness predicted by human muscle microtissue response to humoral factors

Heta Lad, Judy Correa, Kenneth Wu, Rebecca Anne Gladdy, Margaret S. Herridge, Claúdia C. dos Santos, Sunita Mathur, Jane A. E. Batt, Penney M. Gilbert

This study uses human muscle microtissues to show that humoral factors from ICU patients predict clinical risk factors of ICUAW and CIM.

bioRxiv · Oct 23, 2025 · PreprintBioengineering