Penney M. Gilbert

This study shows that anti-HMGCR and anti-SRP autoantibodies from IMNM patients have distinct direct effects on engineered muscle function, with anti-HMGCR reducing contractile force and anti-SRP causing atrophy without affecting force.

This study uses human muscle microtissues to show that humoral factors from ICU patients predict clinical risk factors of ICUAW and CIM.

This study compares stable isotope tracers and puromycin labeling in measuring muscle protein synthesis in engineered skeletal muscle, finding tracers detect anabolic responses missed by puromycin.

This study compares GLUT4 and GLUT1 expression in 2D myotubes and 3D microtissues, finding higher GLUT4 levels in microtissues but insulin dependency limiting their use for T2D modeling.

The paper identifies Perlecan as a factor that influences muscle stem cell re-quiescence, showing its age-related changes and therapeutic potential.

This paper develops a cryopreservation method for myoblasts in paper-based scaffolds, enabling inter-laboratory studies of skeletal muscle health.

FAST-STEM accelerates human pluripotent stem cell engineering by enabling rapid transgene integration and differentiation into multiple cell types.

This study shows that fibronectin promotes stronger stiffness-dependent responses in human myoblasts compared to laminin and collagen, with softer substrates increasing nuclear wrinkling linked to proliferation.

This paper introduces a toolkit for transgene integration in hiPSCs using a safe-harbour locus, enabling controlled transgene configurations and efficient cellular engineering.

The paper develops synthetic gene circuits in human pluripotent stem cells that convert discrete cell states into analog signals by integrating miRNAs with miSFITs for controlled effector protein production.