Exploring Arylidene-Indolinone Ligands of Autophagy Proteins LC3B and GABARAP
A. N. Leveille, T. Schwarzrock, H. Brown, B. True, J. Plasencia, P. Neudecker, A. Üffing, O. H. Weiergraber, D. Willbold, J. Kritzer
The paper investigates the binding affinity of GW5074 to LC3B and GABARAP using an AlphaScreen assay, finding micromolar inhibitory potencies and suggesting potential for targeted protein degradation.
bioRxiv · Feb 25, 2024Biochemistry