H. Brown

Whole-body PET imaging of SIV using anti-Env probes fails to reveal regions of specific uptake in rhesus macaques

This study evaluates two anti-gp120 antibodies for immunoPET imaging of SIV in rhesus macaques and finds no specific uptake, suggesting inadequate binding potential for in vivo imaging.

Exploring Arylidene-Indolinone Ligands of Autophagy Proteins LC3B and GABARAP

The paper investigates the binding affinity of GW5074 to LC3B and GABARAP using an AlphaScreen assay, finding micromolar inhibitory potencies and suggesting potential for targeted protein degradation.

GABA(A) receptor activation drives GABARAP-Nix mediated autophagy to radiation-sensitize primary and brain-metastatic lung adenocarcinoma tumors

This paper shows that activating GABA(A) receptors in lung cancer cells triggers autophagy via GABARAP-Nix interaction, enhancing radiation sensitivity and reducing toxicity in preclinical models.

First Eurasian cases of SARS-CoV-2 seropositivity in a free-ranging urban population of wild fallow deer

The paper reports the first cases of SARS-CoV-2 seropositivity in Eurasian fallow deer, showing increased seroprevalence with emerging variants.

Newly born mesenchymal cells disperse through a rapid mechanosensitive migration

The paper shows newly born mesenchymal cells migrate rapidly and are recruited to dermal condensates due to mechanosensitivity to tissue tension.

Overexpression of AMPKγ2 increases AMPK signaling to augment human T cell metabolism and function

This study shows that overexpressing AMPKγ2 in human T cells enhances oxidative metabolism, improves expansion, and boosts function under low glucose conditions.

Perception of structurally distinct effectors by the integrated WRKY domain of a plant immune receptor.

This paper reveals how the WRKY domain of the Arabidopsis NLR receptor RRS1 recognizes structurally distinct bacterial effectors to initiate immunity.

Expression of type I interferon-associated genes at antiretroviral therapy interruption predicts HIV virological rebound

The paper identifies type I interferon-associated gene expression in CD4 T cells as a predictor of delayed HIV viral rebound after antiretroviral therapy interruption.

The transcription factor Pdr802 regulates Titan cell formation, quorum sensing, and pathogenicity of Cryptococcus neoformans

Establishment of a pig influenza challenge model for evaluation of monoclonal antibody delivery platforms

This study establishes a pig influenza model to evaluate monoclonal antibody efficacy against H1N1, showing dose-dependent reduction in viral load and lung pathology.

Estradiol-inducible AvrRps4 expression reveals distinct properties of TIR-NLR-mediated effector-triggered immunity

The paper induces AvrRps4 expression in Arabidopsis to study RRS1/RPS4-mediated immunity without pathogen presence, revealing downstream immune responses.

HIV reservoir size is determined prior to ART initiation and linked to CD8 T cell activation and memory expansion

This study finds that pre-ART HIV DNA levels predict reservoir size one year after treatment initiation during primary HIV infection, linked to CD8 T cell activation and memory expansion.

A novel bioreactor technology for modelling fibrosis in human and rodent precision-cut liver slices.

This paper develops a bioreactor system that extends the viability of precision-cut liver slices (PCLS) to 6 days under normoxic conditions and demonstrates its use in modeling fibrogenesis and testing anti-fibrotic drugs.

Loss of charge at solvent exposed Lys residues does not induce the aggregation of superoxide dismutase 1

This study shows that losing positive charge at surface lysine residues in SOD1 does not cause misfolding or aggregation, suggesting these mutations are not disease drivers.

Super-multiplexed fluorescence microscopy via photostability contrast

This paper introduces a method to increase fluorescence microscopy multiplexing by using photostability differences and a novel unmixing algorithm, enabling up to three labels per spectral channel.

Enrichment of the HIV reservoir in CD32+ CD4 T cells occurs early in blood and tissue

The paper shows HIV DNA enrichment in CD32+ CD4 T cells early in infection but finds no correlation with rebound viraemia or HIV DNA levels.