D. Willbold

EGFR meets hATG8s - Biophysical and structural insights supporting a unique role of GABARAP during receptor trafficking

The paper identifies a GABARAP binding site on EGFR and shows its role in EGFR degradation through biophysical and structural analysis.

Exploring Arylidene-Indolinone Ligands of Autophagy Proteins LC3B and GABARAP

The paper investigates the binding affinity of GW5074 to LC3B and GABARAP using an AlphaScreen assay, finding micromolar inhibitory potencies and suggesting potential for targeted protein degradation.

Highlighting the hidden: A tagging strategy for monitoring the association of GABARAP with microtubules in living cells

This study introduces a split-tandem GABARAP construct to monitor its association with microtubules in living cells, revealing a robust interaction not observed with N-terminal fluorescent tags.

Tau protein aggregation associated with SARS-CoV-2 main protease

The paper investigates whether SARS-CoV-2 3CL protease induces protein aggregation, including tau, which may contribute to neuropathology associated with COVID-19.

LZTR1 polymerization provokes cardiac pathology in recessive Noonan syndrome

This study identifies a novel LZTR1 variant causing cardiac hypertrophy by altering protein polymerization and ubiquitin ligase function, showing genetic correction can rescue the phenotype.

Design of D-amino acids SARS-CoV-2 Main protease inhibitors using the cationic peptide from rattlesnake venom as a scaffold

The paper designs D-amino acid-based inhibitors of SARS-CoV-2 3CLpro using a rattlesnake venom peptide scaffold, showing in vitro and in vivo antiviral activity.

Structural Basis for the Inhibition of IAPP Fibril Formation by the Hsp60 Co-Chaperonin Prefoldin

This study shows how prefoldin inhibits IAPP fibril formation by binding to the N-terminal segment of IAPP on fibril surfaces and ends, reducing aggregate size and number.

The repurposed drugs suramin and quinacrine inhibit cooperatively in vitro SARS-CoV-2 3CLpro

This study shows that quinacrine and suramin inhibit SARS-CoV-2 3CLpro synergistically in vitro through competitive and non-competitive mechanisms.

Biophysical and dynamic characterization of a fine-tuned binding of the human Respiratory Syncytial Virus M2-1 core domain to long RNAs

This paper characterizes the biophysical and dynamic properties of the hRSV M2-1 core domain binding to long RNAs, revealing a fine-tuned interaction that promotes RNA unfolding.

Amyloid fibril structure of islet amyloid polypeptide by cryo-electron microscopy reveals similarities with amyloid beta

This study uses cryo-EM to reveal the structure of IAPP fibrils, showing similarities with Aβ polymorphs and linking genetic mutations to amyloid formation.

An engineered monomer binding-protein for α-synucleinefficiently inhibits the proliferation of amyloid fibrils

The paper engineers a monomer-binding protein that inhibits α-synuclein fibril proliferation in vitro and in vivo, showing it reduces aggregates and related pathologies.

Structural Insights into Curli CsgA Cross-β Fibril Architecture Inspired Repurposing of Anti-amyloid Compounds as Anti-biofilm Agents

This paper reveals structural similarities between bacterial curli amyloids and human pathological amyloids, leading to the repurposing of anti-amyloid drugs as anti-biofilm agents.

An atomic-scale view at the composition ofamyloid-beta fibrils by atom probe tomography

The paper uses atom probe tomography to analyze the composition of amyloid-beta fibrils at the atomic scale, revealing structural and chemical details.

A structural and kinetic link between membrane association and amyloid fibril formation of α-Synuclein

This study investigates how α-Synuclein interacts with membrane surfaces and how these interactions influence its aggregation into amyloid fibrils.