Distinct modulation of calcium-activated chloride channel TMEM16A by a novel drug-binding site
J. W. Roh, H. Y. Gee, B. Wainger, W. K. Kim, W. Lee, J. H. Nam
The paper identifies a novel non-pore drug-binding site in TMEM16A using magnolol and honokiol, showing distinct inhibitory mechanisms through electrophysiology and molecular simulations.
bioRxiv · Aug 6, 2023 · PreprintPhysiology