W. Lee

RBP4 functions as an antagonistic ligand of orphan DR6

This study identifies RBP4 as an antagonistic ligand of DR6, showing it prevents DR6-driven neurodegeneration by promoting dimerization and blocking prodegenerative interactions.

Gut microbial community in proboscis monkeys (Nasalis larvatus): implications for effects of geographical and social factors

This study analyzes the gut microbiota of proboscis monkeys to assess how geographical and social factors influence their microbial communities.

Targeting the Hippo pathway in cancers via ubiquitination dependent TEAD degradation

This study identifies RNF146 as an E3 ubiquitin ligase that degrades TEAD proteins via the proteasome, showing that pharmacological induction of TEAD ubiquitination can suppress YAP/TAZ-driven cancer growth.

Distinct modulation of calcium-activated chloride channel TMEM16A by a novel drug-binding site

The paper identifies a novel non-pore drug-binding site in TMEM16A using magnolol and honokiol, showing distinct inhibitory mechanisms through electrophysiology and molecular simulations.

Multi-frame biomechanical and relaxometry analysis during in vivo loading of the human knee by spiral dualMRI and compressed sensing

This study uses spiral DENSE MRI and compressed sensing to analyze knee cartilage biomechanics during in vivo loading, showing strain patterns and reduced scan times.

Discovery and biosynthesis of imidazolium antibiotics from a probiotic Bacillus licheniformis

The paper identifies a novel imidazolium antibiotic from Bacillus licheniformis and proposes its biosynthetic pathway through various experimental methods.

Apolipoprotein A1 and high-density lipoprotein limit low-density lipoprotein transcytosis by binding scavenger receptor B1

This study shows that APOA1 and HDL reduce LDL transcytosis by competing with LDL for SR-B1 binding, thereby limiting atherosclerosis.

Q-SHINE: a versatile sensor for glutamine measurement via ligand-induced dimerization

The paper introduces Q-SHINE, a sensor for measuring glutamine levels through ligand-induced dimerization, enabling accurate detection in bio-fluids and living cells.

High-frame-rate analysis of knee cartilage deformation by spiral dualMRI and relaxation mapping

This study uses high-frame-rate MRI and relaxometry to analyze knee cartilage deformation during walking, identifying strain patterns and viscoelastic responses that differentiate healthy from damaged joints.

Extracellular Matrix Modulates Outgrowth Dynamics in Ovarian Cancer

This study shows that extracellular matrix (ECM) concentration modulates outgrowth formation in ovarian cancer cells by altering physical properties like elasticity and fibrous network thickness.

Cryo-EM structure of human somatostatin receptor 2 complex with its agonist somatostatin delineates the ligand binding specificity

The paper reports the cryo-EM structure of human SSTR2 bound to somatostatin, revealing ligand binding specificity and interactions with Gi proteins.

Comparison of Plaque Size, Thermal Stability, and Replication Rate among SARS-CoV-2 Variants of Concern

This study compares plaque size, thermal stability, and replication rates of four SARS-CoV-2 variants of concern and finds differences in these characteristics among them.

Chemical Reversible Crosslinking Enables Measurement of RNA 3D Distances and Alternative Conformations in Cells

This paper introduces SHARC, a method to measure RNA 3D distances and alternative conformations in cells, revealing RNA structures and improving 3D modeling.

Steroid hormone catabolites activate the pyrin inflammasome through a non-canonical mechanism

This study identifies steroid hormone catabolites as specific activators of the pyrin inflammasome through a non-canonical mechanism, linking them to autoinflammation and explaining steroid fever.

pH-dependent polymorphism of the structure of SARS-CoV-2 nsp7

This study determines the solution structure of SARS-CoV-2 nsp7 at pH 7.0 using NMR spectroscopy and identifies pH-dependent structural changes in the protein.

Distinct inflammatory and transcriptomic profiles in dominant versus subordinate males in mouse social hierarchies

This study compares inflammatory and transcriptomic profiles between dominant and subordinate male mice, finding status-related differences in immune investment and gene expression.

Effect of knee joint loading on chondrocyte mechano-vulnerability and severity of post-traumatic osteoarthritis induced by ACL-injury in mice

This study examines how different mechanical loads after ACL injury in mice affect chondrocyte vulnerability and OA progression, finding that lower joint-loading delays OA.

Chitinase 3-like-1 Contributes to Acetaminophen-induced Liver Injury by Promoting Hepatic Platelet Recruitment

This study identifies Chi3l1 as a key mediator of acetaminophen-induced liver injury by promoting hepatic platelet recruitment through the CD44 axis.

CCR2 Regulates Vaccine-Induced Mucosal T cell Memory to Influenza A Virus

This study shows that CCR2 deficiency enhances vaccine-induced lung-resident memory T cells against influenza A virus by reducing monocyte trafficking and promoting mucosal imprinting.

Subunit Vaccine-Elicited Effector-Like Memory CD8 T cells Protect Against Listeriosis

This paper shows that the nanoemulsion adjuvant ADJ alone generates protective CD8 T cell memory against listeriosis, while combining it with TLR agonists reduces memory and immunity.

Solution structures of the Shewanella woodyi H-NOX protein in the presence and absence of soluble guanylyl cyclase stimulator IWP-051

This study reports the NMR structures of Shewanella woodyi H-NOX protein with and without IWP-051, revealing conformational changes and dynamic behavior in the binding pocket.

Nano-Emulsion Adjuvant Enhances Cross-presentation by Lipid Body Formation Independent of Glycolysis

This study shows that the nano-emulsion adjuvant Adjuplex enhances cross-presentation in dendritic cells without requiring glycolysis, relying instead on lipid body formation and ROS.

IER5, a DNA-damage response gene, is required for Notch-mediated induction of squamous cell differentiation

The paper identifies IER5 as a Notch-induced DNA-damage response gene required for squamous cell differentiation and shows its interaction with PP2A subunit PPP2R2A.

Mapping cellular-scale internal stiffness in 3D tissues with smart material hydrogel probes

The paper develops smart material microgels to measure cellular-scale stiffness in 3D tissues and identifies high stiffness regions in cancer spheroids and tumors.

Atrous Convolution with Transfer Learning for Skin Lesions Classification

This paper applies atrous convolution with transfer learning to classify skin lesions using the HAM10000 dataset, achieving high accuracy with efficient models.

Temporal microstructure of dyadic social behavior during relationship formation in mice

The paper analyzes the temporal dynamics of dominant-subordinate relationships in mice using burst detection and behavioral state transitions to show changes in behavior post-resolution.

Comparative Tn-Seq reveals common daptomycin resistance determinants in Staphylococcus aureus despite strain-dependent differences in essentiality of shared cell envelope genes

This paper uses Tn-Seq to compare gene essentiality across multiple S. aureus strains, identifying common resistance determinants and strain-dependent differences under daptomycin exposure.

Social hierarchy position in female mice is associated with plasma corticosterone levels and hypothalamic gene expression

This study examines social hierarchy in female mice, finding that dominant females have higher corticosterone levels and different hypothalamic gene expression compared to subordinates.

A real-time PCR for the differentiation of typhoidal and non-typhoidal Salmonella

This paper develops a real-time PCR assay to rapidly and accurately differentiate typhoidal and non-typhoidal Salmonella with 100% sensitivity and specificity.

Protocol-dependent differences in IC50 values measured in hERG assays occur in a predictable way and can be used to quantify state preference of drug binding.

This study shows that IC50 differences in hERG assays depend predictably on drug binding states and can be modeled using machine learning.