Loss of polr1c disrupts myelination in a zebrafish model of POLR1C-associated disease
Lauren B. Sands, Camille E. A. Goo, Laura K. White, Bailey T. Lubash, Mary Cathleen McKinney, Fengli Guo, Chris W. Seidel, Xia Zhao, Paul A. Trainor, Kristin E. Noack Watt
This study shows that loss of polr1c in zebrafish causes reduced myelination and craniofacial defects, with Tp53 pathway activation but no apoptosis in oligodendrocyte precursors.
bioRxiv · Sep 25, 2026 · PreprintDevelopmental Biology