Targeting RhoA activity rejuvenates aged hematopoietic stem cells
Eva Mejía-Ramírez, Pablo Iáñez Picazo, Barbara Walter, Sara Montserrat‐Vazquez, Francesco Affuso, Stefan Wieser, Fabio Pezzano, Loïc Reymond, Jorge Castillo‐Robles, Francesca Matteini, Loris Mularoni, Dídac Macià, Ángel Raya, Verena Ruprecht, Yi Zheng, , Maria Carolina Florian
This study shows that reducing RhoA activity in aged HSCs lowers nuclear tension, restores chromatin structure, and improves regenerative capacity and lineage balance.
bioRxiv · Apr 23, 2025 · PreprintCell Biology