Verena Ruprecht

The paper shows that de novo E-cadherin/catenin complex formation at the phagocytic synapse regulates epithelial mechanics and force transmission for apoptotic cell clearance in zebrafish and mouse.

This paper develops a theoretical model to simulate phagocytosis of deformable targets and identifies three mechanical regimes based on target stiffness, validated experimentally with GUVs and lymphoma cells.

This study shows that mechanical confinement causes mitochondria to relocate to the nucleus, leading to a nuclear ATP surge that supports DNA repair and cell cycle progression.

This study shows that reducing RhoA activity in aged HSCs lowers nuclear tension, restores chromatin structure, and improves regenerative capacity and lineage balance.

This paper introduces a time-shared optical tweezer microrheology method to measure age-dependent viscoelastic properties of biological materials, demonstrating its application in biomolecular condensates, zebrafish cells, and C. elegans.

This study identifies mechanical phenotype differences between LGR5+ and LGR5- colorectal cancer cells, linking them to membrane to cortex attachment proteins and metastatic potential.

This study identifies TLR2 as a target to counteract adaptation to ARF6 depletion in KRAS-driven PDAC, reducing proliferation, migration, and invasion.

The paper identifies Srrm3-dependent microexons as critical for photoreceptor function and vision, showing their role in outer segment maintenance and their loss leading to blindness.