Dual-inactivation of Regnase-1 and SOCS1 rewires exhausted CD8+ T cell fate to enhance anti-tumor functionality
Isabelle Le Mercier, David Monteiro, Katarina Halpin-Veszeleiova, Karrie Ka Wai Wong, Anne E. Dodson, Gustavo J. Martinez, Dominick A. Matos, Bashar M. Hamza, Ashish Yeri, Seamus McKenney, Sharon Lin, Nicole Protheroe, Alex Smashnov, Paul Dunbar, Mitali Ghose, , Micah J. Benson
This study identifies Regnase-1 and SOCS1 dual-inactivation as a strategy to enhance anti-tumor functionality of CD8+ T cells by rewiring their differentiation and effector state.
bioRxiv · Jan 23, 2026 · PreprintImmunology