Beatriz Goncalves

Loss of PKN2 drives fibroblast reprogramming and extracellular matrix remodelling in pulmonary fibrosis

This study shows that loss of PKN2 leads to fibroblast reprogramming and ECM remodelling in pulmonary fibrosis by altering key pathways and secretion.

Rapid Assessment of Immune Effector Cell-mediated Cytotoxicity using mRNA Lipid Nanoparticles

This paper introduces an mRNA-LNP method to assess immune effector cell-mediated cytotoxicity, showing it is rapid, consistent, and compatible with diverse tumor models.

DR5 CAR-T cells target solid tumors and suppress MDSCs with minimal toxicity

This study develops DR5-targeted CAR-T cells that kill solid tumors and MDSCs, enhance CD8+ T cell activity, and show minimal toxicity in preclinical models.

Directed evolution-based discovery of ligands for in vivo restimulation of CAR-T cells

This study develops a method to generate optimized peptide ligands for CAR-T cell restimulation, demonstrating enhanced expansion and memory development in preclinical models.