Ribophorin-1 Governs Spike Abundance of Highly Pathogenic Coronaviruses by ER-associated degradation
Yi-Jiao Huang, Lu Lv, Wei Ran, Hongyun Zhao, Yong-Qiang Deng, Qing Ye, Lin Li, Xiao-Yan Wu, Qi Chen, Yi Hu, Bei Sun, Jianjun Zhao, Jincun Zhao, 秦成峰
This study identifies Ribophorin-1 as a host factor that reduces spike protein abundance on coronaviruses by promoting its degradation, thereby inhibiting infection.
bioRxiv · May 21, 2026 · PreprintMicrobiology