PUMILIO hyperactivity drives premature aging of Norad-deficient mice
Florian B. Kopp, Mehmet Emir YALVAÇ, Beibei Chen, He Zhang, 이성율, Frank A Gillett, Mahmoud M. Elguindy, Sushama Sivakumar, Hongtao Yu, Yang Xie, Prashant Mishra, Zarife Sahenk, Joshua T. Mendell
This study shows that loss of the lncRNA Norad leads to PUMILIO hyperactivity, causing genomic instability and mitochondrial dysfunction, resulting in premature aging in mice.
eLife · Feb 8, 2019Peer-reviewedMolecular Biology