Prashant Mishra

This study identifies UFMylation of PDH as a regulator of mitochondrial metabolism, showing it enhances pyruvate oxidation and TCA cycle activity.

This study uses mouse models to investigate mitochondrial metabolism in specific kidney tubular cell types and finds differences in mitochondrial function under fasting conditions.

This study shows mutant IDH reprograms neural progenitor cell fate by silencing Gsx2, promoting gliomagenesis through lineage switching.

This study investigates how CIDEB loss-of-function mutations protect against fatty liver disease by enhancing β-oxidation through ATGL and PPARα activation.

This study shows that pathogenic mtDNA mutations in melanoma cells reduce metastasis by limiting circulation entry, despite promoting tumor growth.

This study shows that loss of the lncRNA Norad leads to PUMILIO hyperactivity, causing genomic instability and mitochondrial dysfunction, resulting in premature aging in mice.