Min Chen

A direct RNA sequencing workflow for simultaneous profiling of tRNA abundance and modifications in mouse liver

This paper introduces a direct RNA sequencing workflow to profile tRNA abundance and modifications in mouse liver, identifying key modification sites and isotype-specific patterns.

KMT2E recruitment by H3 serotonylation regulates neurodevelopmental chromatin dynamics

This study identifies KMT2E as a reader of H3K4me3Q5ser, showing its role in regulating chromatin dynamics and neurodevelopmental gene expression in ODLURO syndrome.

A self-limiting, TREM2-dependent anabolic program confers microglial resilience in Alzheimer's disease

The paper shows that TREM2-dependent anabolic programs in microglia decline with advancing Alzheimer's disease, linking anabolic capacity to microglial resilience rather than activation state.

An INSR-BECN1-KIAA0825 complex prevents hepatocytic insulin receptor secretion via extracellular vesicles against monogenic diabetes

This study identifies an INSR-BECN1-KIAA0825 complex that regulates INSR trafficking and function in hepatocytes, revealing how its disruption leads to monogenic diabetes.

Quinone reductase 2 reads H3 serotonylation to support human cortical neuron development

This study identifies QR2 as a reader of H3Q5ser, showing its role in human neuron development through transcriptional and electrophysiological effects.

Polymer-lipid hybrid nanoparticle enhances mRNA delivery and T cell-mediated immunity

This study develops a polymer-lipid hybrid nanoparticle (PLNP) to enhance mRNA delivery and T cell immunity, showing improved antigen-specific T cell responses and protection against viral variants and cancer.

ZBTB7A regulates MDD-specific chromatin signatures and astrocyte-mediated stress vulnerability in orbitofrontal cortex

The paper identifies ZBTB7A as a key regulator of MDD-specific chromatin signatures and astrocyte-mediated stress vulnerability in the orbitofrontal cortex.

Reference-free and de novo Identification of Circular RNAs

The paper introduces a reference-free method, Cirit, for de novo detection of circRNAs from NGS transcriptomes, identifying 28,813 human circRNAs and highlighting their diverse expression patterns and splicing mechanisms.

Identification and characterization of cherry (Cerasus pseudocerasus G. Don) genes in response to parthenocarpy induced by GA3 through transcriptome analysis

The paper identifies DEGs in sweet cherries responding to GA3-induced parthenocarpy and finds patterns related to hormone balance, cytoskeleton, and cell wall modification.

Toxoplasma gondii ROP18 Inhibits Human Glioblastoma Cell Apoptosis through Mitochondrial Pathway by Targeting Host Cell P2X1

Sugar metabolism changes in response to the ultraviolet B irradiation of peach (Prunus persica L.)

The paper investigates how ultraviolet B radiation affects sugar metabolism in peach, finding increased sucrose and sorbitol levels in fruit, peel, and leaves.

RSQ: a statistical method for quantification of isoform-specific structurome using transcriptome-wide structural profiling data

RSQ quantifies isoform-specific structurome by modeling read distribution across isoforms and RNA conformations, enabling comparison between conditions and analysis of conformational variation.

An integrative somatic mutation analysis to identify pathways linked with survival outcomes across 19 cancer types

This study identifies cancer-type-specific altered pathways linked to survival outcomes across 19 cancer types using integrated somatic mutation and gene expression data.