TRAPPC8 Is an Endogenous Brake on UFMylation That Suppresses Tauopathy
Yuansong Wan, Ethan Cordes, Weixi Feng, Se-In Lee, Katie Munechika, Yu Sun, Zhisong Gao, Beichen Gao, Jingjie Zhu, Man Ying Wong, Kendra Norman, Siyu Wang, hao chen, Bangyan Liu, Zhong Li, , Li Gan
This study identifies TRAPPC8 as a brake on UFMylation that suppresses tauopathy by interacting with UBA5, showing its therapeutic potential in Alzheimer's disease.
bioRxiv · Aug 23, 2026 · PreprintNeuroscience