Yu Sun

KRT7CreER Ferrets Enable Lineage Tracing of Ductal Epithelia and Pancreatic Remodeling

This study uses KRT7CreER ferrets to trace ductal epithelial lineage and pancreatic remodeling in health and cystic fibrosis.

A Cis-Element in magu-2 Mediates Apical mRNA Localization via Active Transport in C. elegans

VASP association stabilizes the actin nucleus revealed by molecular dynamics simulations

This study uses molecular dynamics simulations to show that VASP stabilizes actin trimers by preferentially anchoring a subunit and preserving conformational heterogeneity.

A self-limiting dimeric TIR effector specialised for type III CRISPR-mediated immunity

The paper describes a dimeric TIR effector, TSR1, that binds cA3 and degrades it to auto-limit its activity in type III CRISPR-mediated antiviral immunity.

TRAPPC8 Is an Endogenous Brake on UFMylation That Suppresses Tauopathy

This study identifies TRAPPC8 as a brake on UFMylation that suppresses tauopathy by interacting with UBA5, showing its therapeutic potential in Alzheimer's disease.

Phagocytic activity of perivascular cell promotes CNS injury pathology

The paper identifies perivascular cells as phagocytes that clear CNS debris and shows Axl inhibition reduces pathology and improves recovery after spinal cord injury.

A Deep Learning Framework for Biomarker Segmentation and Classification in Traumatic Brain Injury

This paper introduces a deep learning framework for automated segmentation and classification of traumatic brain injury using GFAP and IBA1 biomarkers, showing improved performance over manual methods.

Genome-wide CRISPR screen reveals PEX11B as a host restriction factor against ORFV through membrane fluidity regulation

The paper identifies PEX11B as a host restriction factor against ORFV by showing its role in regulating membrane fluidity and peroxisomal integrity.

POGZ safeguards neuronal gene chromatin architecture and transcription

This paper investigates the role of POGZ in maintaining chromatin architecture and transcription in the developing mouse cortex, finding that its loss disrupts H3K9me3 distribution and impairs neuronal gene expression.

Survey of Climate-structured Mycobiomes in Staple Maize: Implications for Endemic Keshan and Kashin-Beck Diseases

The paper profiles maize-associated fungal communities in regions endemic for Keshan and Kashin-Beck diseases, finding regional differences linked to climate and disease risk.

Interactome mapping in human excitatory neurons reveals novel risk genes and pathways in Alzheimer's disease

The paper develops a neuron-specific interactome map in human excitatory neurons to identify novel risk genes and pathways in Alzheimer's disease.

Structural Basis of Asymmetric Class C GPCR activation and distinct Gq coupling induced by force stimulation

This paper reveals how mechanical force activates mGlu2 through a unique cis mechanism and induces distinct Gq coupling, providing structural insights and a chemical toolset for modulating mechanosensitive GPCRs.

Decoding with multivariate pattern analysis is superior for optically pumped magnetometer-based magnetoencephalography compared to superconducting quantum interference device-based systems

This study compares decoding accuracy of visual processing using optically pumped magnetometer (OPM) and superconducting quantum interference device (SQUID) based magnetoencephalography (MEG) systems with multivariate pattern analysis (MVPA).

Kinase independent function of PI3Kγ modulates calcium re-uptake by regulating phospholamban function

This study shows that PI3Kγ regulates calcium re-uptake in cardiomyocytes by modulating phospholamban phosphorylation through PP2A, independent of its kinase activity.

Small Heat Shock Proteins and Eicosanoid Pathways Modulate Caspase-1 Activity in the Fat Bodies of Antheraea pernyi

This study investigates how heat shock preconditioning and eicosanoid pathway modulations affect caspase-1 activity and Hsp 20.8 synthesis in the fat bodies of Antheraea pernyi after heat shock injury.