Targeting the RNA regulator HuR in acute traumatic brain injury mitigates secondary injury and improves functional outcome by suppressing neuroinflammation
Mohammed Amir Husain, Ben Sheline, Reed Smith, Oanh T P Trinh, Ying Si, Annye Bennett, Mark Bolding, Shreyas Keshava, Burt Nabors, Natalia Filippova
This study shows that inhibiting HuR with SRI-42127 reduces neuroinflammation and secondary injury after TBI, improving functional outcomes in mice.
bioRxiv · Oct 30, 2026 · PreprintNeuroscience