T Cells Tear Apart Confining Extracellular Matrix Via a Breaststroke-like Motion to Generate Migration Paths
Byung Hang Ha, Peter Xie, Benjamin Johns, Cole Allan, Maria Moozhiyil Korah, Daniel Delitto, Paul L. Bollyky, Natalie Julia Torok, Ovijit Chaudhuri
This study shows T cells generate migration paths in confining ECMs by tearing them apart with breaststroke-like motion, finding that shear strength, not stiffness or pore size, correlates with migration.
bioRxiv · Oct 3, 2025 · PreprintBiophysics