Human CD8-iTreg are potent GVHD suppressors and tumoricidal effectors by release of Granzyme-K+ Supramolecular Attack Particles
Jemma H. Larson, Ewoud Bernardus Compeer, Phillip R. Dougherty, Kyle Smith, Michael C. Zaiken, Olga Margaritaki, Benn Kopp, Sujeong Jin, Maria Harkiolaki, Lina Chen, Salvatore Valvo, Claire C. Staton, Nagaja Capitani, Chiara Cassioli, Nathaniel C. Payne, , Bruce R. Blazar
This study identifies CD8-iTreg as potent anti-tumor effectors and GVHD suppressors through Granzyme-K+ supramolecular attack particles.
bioRxiv · Jun 23, 2026 · PreprintImmunology