Author

Kyle Smith

St. Jude Children's Research Hospital

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

Biology Disciplines

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Bioinformatics· 1 Cancer Biology· 1 Immunology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Assay:scRNA-seq· 4 Organism:human· 3 Research Focus:benchmarking· 2 Research Focus:cell type annotation· 2 Approach:deep learning· 2 Approach:statistical model· 2 Research Focus:cell-cell communication· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

Paul A. NorthcottiD· 2 shared Alexandra Grella· 1 shared Alexandre Gaspar‐MaiaiD· 1 shared Andre Kurlovs· 1 shared Arzu Onar‐ThomasiD· 1 shared Ayesha A. Malik· 1 shared Ayla Bratton· 1 shared B Houle· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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2 shared papersCancer Biology

Paul A. NorthcottORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Human CD8-iTreg are potent GVHD suppressors and tumoricidal effectors by release of Granzyme-K+ Supramolecular Attack Particles

Jemma H. Larson, Ewoud Bernardus Compeer, Phillip R. Dougherty, Kyle Smith, Michael C. Zaiken, Olga Margaritaki, Benn Kopp, Sujeong Jin, Maria Harkiolaki, Lina Chen, Salvatore Valvo, Claire C. Staton, Nagaja Capitani, Chiara Cassioli, Nathaniel C. Payne, , Bruce R. Blazar

This study identifies CD8-iTreg as potent anti-tumor effectors and GVHD suppressors through Granzyme-K+ supramolecular attack particles.

bioRxiv · Jun 23, 2026 · PreprintImmunology

Human stem cell models for group 3 medulloblastoma uncover JARID1B as a regulator of the chromatin landscape.

Zulekha A. Qadeer, Elise Hou, Dara Siegel, Samantha Westelman, Brian L. Gudenas, Kyle Smith, Wazim Mohammed Ismail, Linyu Wang, Mackenzie Johnson, Shane Grele, Ronald Phua, Liam D. Hendrikse, Ekin Güney, Miller Huang, Alexandre Gaspar‐Maia, , William A. Weiss

bioRxiv · Dec 8, 2025 · PreprintCancer Biology

Single-cell neural network classifiers reveal that PM21 NK cell expansion is dependent on B cell signaling

Michael Tsabar, Shaoline Sheppard, Sarah Sturtevant, Yinyin Huang, Ryan M. J. Genga, Margaret E. Magaletta, Matthew P. Kodrasov, Elizabeth Tran, Kyle Smith, Juhyung Jung, Matthew Sullivan, Andre Kurlovs, Virginia Savova, Diana Stoycheva, Bruno Figueroa, , Giorgio Gaglia

The paper uses single-cell transcriptomics and neural network classifiers to identify B cell signaling as critical for NK cell expansion in allogenic therapy.

bioRxiv · Sep 23, 2025 · PreprintSystems Biology

MODE: high-resolution digital dissociation with deep multimodal autoencoder

Jiao Sun, Ayesha A. Malik, Tong Lin, Ayla Bratton, Yue Pan, Kyle Smith, Arzu Onar‐Thomas, Giles W. Robinson, Wei Zhang, Paul A. Northcott, Qian Li

MODE improves deconvolution by integrating multi-omic data through a multimodal autoencoder, outperforming existing methods in simulation and real data.

bioRxiv · Jan 2, 2025 · PreprintBioinformatics