Author

Bernd Zetsche

Broad Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:CRISPR screen· 2 Organism:mouse· 2 Research Focus:perturbation response prediction· 2 Research Focus:benchmarking· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

David A. ScottiD· 3 shared Feng ZhangiD· 3 shared Jonathan S. GootenbergiD· 2 shared Omar O. AbudayyehiD· 2 shared Ellen M. DeGennaroiD· 1 shared Erik WernerssoniD· 1 shared Iana FedorovaiD· 1 shared Jeroen KneppersiD· 1 shared

Activity by Year

2016-2017 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersMolecular Biology

David A. ScottORCID

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3 papers

Recent·Most cited

A Survey of Genome Editing Activity for 16 Cpf1 orthologs

Bernd Zetsche, Jonathan G. Strecker, Omar O. Abudayyeh, Jonathan S. Gootenberg, David A. Scott, Feng Zhang

The paper tests 16 Cpf1 orthologs for genome editing activity in eukaryotic cells, identifying four active enzymes including Mb3Cpf1 with robust indel formation and PAM tolerance.

bioRxiv · May 4, 2017 · PreprintMolecular Biology

Multiplex gene editing by CRISPR-Cpf1 through autonomous processing of a single crRNA array

Bernd Zetsche, Matthias Heidenreich, Prarthana Mohanraju, Iana Fedorova, Jeroen Kneppers, Ellen M. DeGennaro, Nerges Winblad, Sourav Choudhury, Omar O. Abudayyeh, Jonathan S. Gootenberg, Wen Y. Wu, David A. Scott, Konstantin Severinov, John van der OOST, Feng Zhang

The paper demonstrates multiplex gene editing in mammalian cells and mouse brains using a single CRISPR array processed by Cpf1 without requiring additional factors.

Nature Biotechnology · Feb 1, 2017Peer-reviewedMolecular Biology

BLISS: quantitative and versatile genome-wide profiling of DNA breaks in situ

Winston X. Yan, Reza Mirzazadeh, Silvano Garnerone, David A. Scott, Martin Schneider, Tomasz Kallas, Joaquín Custodio, Erik Wernersson, Linyi Alex Gao, Yinqing Li, Yana Federova, Bernd Zetsche, Feng Zhang, Magda Bienko, Nicola Crosetto

BLISS quantifies DNA double-strand breaks in situ with high sensitivity and efficiency, showing Cpf1 has higher specificity than Cas9.

bioRxiv · Dec 4, 2016 · PreprintMolecular Biology