Nicola Crosetto

The paper identifies trans-contacting intronic RNAs (TIRs) in neuronal cells that form nuclear scaffolds called introsomes, influencing 3D genome organization and gene expression.

This study shows CDK12 prevents transcription-replication conflicts and DNA damage in MYC-overexpressing cells by repressing transcription at damaged genes.

This study shows that HNRNPU deficiency causes chromatin remodeling, transcriptional changes, and delayed neurogenesis in hindbrain-derived neural progenitors.

This study uses deep learning to segment tumor microenvironments in lung cancer images, predicting patient survival and gene mutations with moderate to high accuracy.

The paper shows ERCC1-XPF interacts with TOP IIβ to repair transcription-induced DNA breaks, explaining clinical heterogeneity in related disorders.

The paper develops genome-wide models of DNA double strand break (DSB) susceptibility to identify structural variants (SVs) under positive or purifying selection in cancer.

This paper engineers Cpf1 variants with altered PAM specificities to expand their targeting range while maintaining specificity.

BLISS quantifies DNA double-strand breaks in situ with high sensitivity and efficiency, showing Cpf1 has higher specificity than Cas9.