SIRPalpha+ PD-L1+ bone marrow macrophages aid AML growth by modulating T cell function
Flora Birch, Sara González-Antón, Myriam Luydmila Rachelle Haltalli, Probir Chakravarty, Federica Bruno, Christiana Georgiou, Cera Mai, Yvette Todd, Beth Payne, Sabine Blum, Constandina Pospori, Caroline Arber, Richard J. Burt, Floriane S. Tissot, Cristina Lo Celso
The paper identifies a subpopulation of bone marrow macrophages that support AML growth by inhibiting T cells and are enriched in patients with early relapse.
bioRxiv · Sep 15, 2024 · PreprintCancer Biology