Constitutively active receptor ADGRA3 signaling induces adipose thermogenesis
Zewei Zhao, Longyun Hu, Bigui Song, Tao Jiang, Qian Wu, Jiejing Lin, Xiaoxiao Li, Yi Cai, Jin Li, Bingxiu Qian, Siqi Liu, Jilu Lang, Zhonghan Yang
This study identifies ADGRA3 as a GPCR that promotes adipose thermogenesis through constitutive activity and the Gs-PKA-CREB axis, with hesperetin as a potential agonist for therapeutic obesity treatment.
eLife · Aug 12, 2024Peer-reviewedCell Biology