Cell BiologyeLifePeer-reviewed
Constitutively active receptor ADGRA3 signaling induces adipose thermogenesis
Zewei Zhao, Longyun Hu, Bigui Song…·Zhonghan Yang
This study identifies ADGRA3 as a GPCR that promotes adipose thermogenesis through constitutive activity and the Gs-PKA-CREB axis, with hesperetin as a potential agonist for therapeutic obesity treatment.