Pharmacological up-regulation of CALM1 restore endothelial cells in intracranial aneurysm pathogenesis
Danyi Zheng, Yikui Liu, Lanlan Zhao, Bing Leng, Qingfang Sun, Baofeng Wang, Xuanfeng Qin, Liuguan Bian, Yongtao Zheng
This study identifies compound ZC04329651 as a CALM1 activator that restores endothelial cells in intracranial aneurysms by counteracting senescence and promoting stability.
bioRxiv · Aug 5, 2026 · PreprintCell Biology