Author

Bohan Zhang

Broad Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

Biology Disciplines

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Systems Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Research Focus:differential expression· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Vadim N. GladysheviD· 2 shared Adrian MolièreiD· 1 shared Alexander TyshkovskiyiD· 1 shared Alibek MoldakozhayeviD· 1 shared Andrei V. GudkoviD· 1 shared Chenhui ZhaoiD· 1 shared Chuanhai FuiD· 1 shared Daria I. FleyshmaniD· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersSystems Biology

Vadim N. GladyshevORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Systemic control and inter-organ communication of ovarian aging

Sharif Iqbal, Alexander Tyshkovskiy, Bohan Zhang, Sirui Zhang, Adrian Molière, Kejun Ying, Yunhao Bai, Harlan Steven, Ludger Goeminne, Juan José Alba‐Linares, Erik Jacques, Md Amin Hossain, Dmitrii Glubokov, Alibek Moldakozhayev, Jesse R. Poganik, , Vadim N. Gladyshev

This study shows ovarian aging can shift in both directions depending on the systemic environment through inter-organ communication and molecular changes.

bioRxiv · Oct 13, 2026 · PreprintSystems Biology

Thermodynamic scaling of canine aging and reversible clock deceleration by a reverse transcriptase inhibitor

Simon S. Matrenok, Ekaterina L. Andrianova, Konstantin Avchaciov, Daria I. Fleyshman, Heather Jay Huson, John P. Loftus, Joseph J. Wakshlag, Bohan Zhang, Vadim N. Gladyshev, Andrei V. Gudkov, Peter O. Fedichev

The paper tracks aging in sled dogs using a variational autoregressive model to show that lamivudine temporarily decelerates DNA methylation clocks but not long-term biological age.

bioRxiv · Feb 12, 2026 · PreprintSystems Biology

Calcium directs actin assembly via allosteric activation of formin INF2

Bohan Zhang, Meng Zhang, Ke Liu, Chenhui Zhao, Jianwen Zhang, Zhijun Liu, Ying Fan, Ruo‐Xu Gu, Lin Lin, Chuanhai Fu, Jinwei Zhu

This study identifies Ca2+-CaM as a direct activator of INF2, linking calcium signals to actin assembly and mitochondrial fission through an allosteric mechanism.

bioRxiv · Jan 29, 2026 · PreprintBiochemistry