Author

Erik Jacques

Brigham and Women's Hospital

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Systems Biology· 2 Bioinformatics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 4 Research Focus:cell type annotation· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:benchmark study· 1 Research Focus:benchmarking· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Alexander TyshkovskiyiD· 3 shared Jesse R. PoganikiD· 3 shared Kejun YingiD· 3 shared Vadim N. GladysheviD· 3 shared Alec EamesiD· 2 shared Alibek MoldakozhayeviD· 2 shared Mahdi MoqriiD· 2 shared Sharif IqbaliD· 2 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersSystems Biology

Alexander TyshkovskiyORCID

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Author profile →

4 papers

Recent·Most cited

Systemic control and inter-organ communication of ovarian aging

Sharif Iqbal, Alexander Tyshkovskiy, Bohan Zhang, Sirui Zhang, Adrian Molière, Kejun Ying, Yunhao Bai, Harlan Steven, Ludger Goeminne, Juan José Alba‐Linares, Erik Jacques, Md Amin Hossain, Dmitrii Glubokov, Alibek Moldakozhayev, Jesse R. Poganik, , Vadim N. Gladyshev

This study shows ovarian aging can shift in both directions depending on the systemic environment through inter-organ communication and molecular changes.

bioRxiv · Oct 13, 2026 · PreprintSystems Biology

Aged white adipose tissue is rejuvenated in a young host through thermogenic remodeling of mature adipocytes

Alibek Moldakozhayev, Alexander Tyshkovskiy, Pasquale Nigro, Zehao Zhang, Albina Tskhay, Cecília Gallottini de Magalhães, Shweta Yadav, Kejun Ying, Alec Eames, Jesse R. Poganik, Shakchhi Joshi, Ji Seul Han, Daria Kholdina, Wayne Mitchell, João A. Paulo, , Vadim N. Gladyshev

This study shows that old white adipose tissue can rejuvenate in young hosts through thermogenic remodeling and pathway activation, reversing biological age markers.

bioRxiv · Sep 30, 2026 · PreprintSystems Biology

A Unified Framework for Systematic Curation and Evaluation of Aging Biomarkers

Kejun Ying, Seth Paulson, Alec Eames, Alexander Tyshkovskiy, Siyuan Li, Nir Eynon, Macsue Jacques, Robin Grolaux, Kirsten Seale, Erik Jacques, Ludger J.E. Goeminne, Andrea Cipriano, Martin Felipe Perez-Guevara, Mehrnoosh Emamifar, Maximiliano Casas Martínez, , Vadim N. Gladyshev

The paper develops Biolearn, an open-source framework for curating and evaluating aging biomarkers across datasets, finding that harmonization and standardization improve their performance and generalizability.

Nature Aging · Nov 4, 2025Peer-reviewedBioinformatics

Integrating in silico predictions with an engineered tissue assay identifies Perlecan as an age-perturbed re-quiescence cue for muscle stem cells

Erik Jacques, Pauline Garcia, Orane Mercier, Yechen Hu, Cyril Dégletagne, Jade Ravent, Sidy Fall, Maira P. Almeida, Aaron R. Wheeler, Stéphane Angers, Penney M. Gilbert, Fabien Le Grand

The paper identifies Perlecan as a factor that influences muscle stem cell re-quiescence, showing its age-related changes and therapeutic potential.

bioRxiv · Jul 22, 2024 · PreprintCell Biology