Author

Brian A. Harsch

Pennsylvania State University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Gregory C. SheareriD· 3 shared Chastity L. HealyiD· 2 shared Sara J. Puccini· 2 shared Timothy D. O’ConnelliD· 2 shared Ahmed AhmediD· 1 shared Dylan J. GybergiD· 1 shared John W. I. NewmaniD· 1 shared Julia C. LiuiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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3 shared papersPhysiology

Gregory C. ShearerORCID

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Author profile →

3 papers

Recent·Most cited

Free fatty acid receptor 4 in cardiac myocytes ameliorates ischemic cardiomyopathy

Michael J. Zhang, Sara J. Puccini, Sergey Karachenets, Dylan J. Gyberg, Shanmugasundaram Pakkiriswami, Megan K. Sumera, Ryan Gemilere, Natalie L. Weir, Sebastian L Torres, Chastity L. Healy, Brian A. Harsch, Steven C. Wu, Julia C. Liu, Gregory C. Shearer, Timothy D. O’Connell

This study shows that Ffar4 in cardiac myocytes reduces systolic dysfunction after ischemia-reperfusion by improving mitochondrial function and cGMP signaling.

Cardiovascular Research · Aug 14, 2026Peer-reviewedPhysiology

A Cell Autonomous Free fatty acid receptor 4 - ChemR23 Signaling Cascade Protects Cardiac Myocytes from Ischemic Injury

Sara J. Puccini, Chastity L. Healy, Brian A. Harsch, Ahmed Ahmed, Gregory C. Shearer, Timothy D. O’Connell

This study shows that Ffar4 and ChemR23 signaling in cardiac myocytes protects against ischemic injury by reducing oxidative stress and cell death.

bioRxiv · Nov 26, 2024 · PreprintPhysiology

ABCA1 and apoA-I dependent 12-hydroxyeicosatetraenoic acid efflux regulates macrophage inflammatory signaling

Brian A. Harsch, Kamil Borkowski, Rachel E. Walker, Theresa L. Pedersen, John W. I. Newman, Gregory C. Shearer

The paper investigates how ABCA1 and apoA-I facilitate 12-HETE efflux from macrophages, reducing inflammation by modulating intracellular HETE levels.

bioRxiv · Jul 11, 2024 · PreprintMolecular Biology