Hepatic urea cycle suppression drives brown fat thermogenesis to counter obesity and liver disease
Laura C. Kim, Nicholas P. Lesner, Xuanyan Cai, Xu Han, Jimmy P. Xu, Andy Zhao, Nathan J. Coffey, Denise Zheng, Brian Keith, Clementina Mesaros, Zoltan Arany, Marie Celeste Simon
This study shows that reducing hepatic ASS1 protects against obesity and liver disease by enhancing brown fat thermogenesis.
bioRxiv · Oct 26, 2026 · PreprintCancer Biology