Nathan J. Coffey

This study shows that reducing hepatic ASS1 protects against obesity and liver disease by enhancing brown fat thermogenesis.

This study shows HIF2α prevents GLS1 clustering in mitochondria, protecting ccRCC cells from glutamine deprivation, and suggests targeting GLS1 clustering could enhance HIF2 therapy.

This study shows nuclear speckles vary in cancer, correlate with survival in kidney cancer, and are regulated by HIF-2 through speckle targeting motifs.