Author

Bridget C. Ryan

University of Victoria

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Organism:mouse· 1

Frequent Co-Authors

Robert L. ChowiD· 2 shared Adelaide H. Chow· 1 shared Alex MirandaiD· 1 shared Caitlin N Geczi· 1 shared Christopher J. NelsoniD· 1 shared Connor O’Sullivan· 1 shared David R. GoodlettiD· 1 shared Jennifer L. Christie· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersGenetics

Robert L. ChowORCID

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2 papers

Recent·Most cited

Loss of Complement Factor D suppresses alternative pathway activation but fails to reduce lipofuscin accumulation in the retinal pigmented epithelium of Abca4-/- mice

Bridget C. Ryan, Kaitlin E. Griffith, Caitlin N Geczi, Katerina E. Kurz, Oliver Orchiston, Owen Smith, Xiaoya Xie, Adelaide H. Chow, Robert L. Chow

The paper investigates the role of the alternative complement pathway in Stargardt disease by analyzing Abca4-/- and Cfd-/- mice, finding that while the pathway drives complement activation, it does not reduce lipofuscin accumulation.

bioRxiv · Oct 25, 2025 · PreprintGenetics

Cytoplasmic Switch of ARS2 Isoforms Promotes Nonsense-Mediated mRNA Decay and Arsenic Sensitivity

Monica Mesa-Perez, Phineas T. Hamilton, Alex Miranda, Nicholas I. Brodie, Connor O’Sullivan, Jennifer L. Christie, Bridget C. Ryan, Robert L. Chow, David R. Goodlett, Christopher J. Nelson, Perry L. Howard

The paper shows that alternative splicing of ARS2 generates cytoplasmic isoforms that switch ARS2's function from inhibiting to promoting nonsense-mediated mRNA decay and enhance arsenic stress response.

Nucleic Acids Research · Jan 13, 2022Peer-reviewedMolecular Biology