Molecular BiologyNucleic Acids ResearchPeer-reviewed
Cytoplasmic Switch of ARS2 Isoforms Promotes Nonsense-Mediated mRNA Decay and Arsenic Sensitivity
Monica Mesa-Perez, Phineas T. Hamilton, Alex Miranda…·Perry L. Howard
The paper shows that alternative splicing of ARS2 generates cytoplasmic isoforms that switch ARS2's function from inhibiting to promoting nonsense-mediated mRNA decay and enhance arsenic stress response.