Multivalent Scaffolding by XIST E-Repeats Tunes RNA Binding Protein Cooperativity and Lowers the Phase Separation Threshold
Bryan Eusse, Alfredo Vidal-Ceballos, Andrew K Meyer, R. Alexander Martino, Emma Bose, Karmella Ann Haynes, Alisha N Jones
The paper characterizes the biophysical interactions between XIST E-Repeats and RNA-binding proteins, revealing cooperative binding and phase separation behavior that informs XIST's chromatin-modulating function.
bioRxiv · Oct 27, 2026 · PreprintBiophysics