Christal Dyane Sohl

This study shows mutant IDH1 increases sEV secretion and alters their cargo composition in glioma and chondrosarcoma cells, with D2HG packaged into sEVs and cell-type-specific cargo remodeling.

This study compares the reaction mechanisms of two IDH1 mutants, finding that R132Q has optimized active site conformation for both conventional and neomorphic activity, potentially explaining resistance to inhibitors.

This study shows that IDH1 R132Q mutants produce more D2HG than R132H mutants, leading to more aggressive tumors through distinct epigenetic and transcriptomic changes.