Inhibition of Androgen Receptor Exposes Replication Stress Vulnerability in Prostate Cancer
C Williams, Xin Li, Hongjun Jang, Jay Ramanlal Anand, Won Young Lim, Hyejin Lee, Julie Parks, Xingyuan Zhang, Jialiu Xie, Jinshi Zhao, Di Wu, Andrew J. Armstrong, Jessica L. Bowser, Lee Zou, Jiyong Hong, , Pei Zhou
The paper shows that AR inhibition in prostate cancer causes DNA replication stress, which can be exploited by combining with a TLS inhibitor to enhance treatment efficacy.
bioRxiv · Oct 8, 2024 · PreprintCancer Biology