Xin Li

Human brain white matter charts in international populations

The paper develops population-specific white matter charts for Chinese and Western populations, showing differences in maturation timing and improved prediction accuracy when using population-matched models.

Cause-excluded Effect Evaluation: a framework for the faithful assessment of genetic perturbation target identification

The paper introduces CEE, a framework to assess genetic perturbation target identification by eliminating evaluation artefacts, and finds simple methods outperform complex models.

The cleaved C-terminal domain of GmERS1-1 modulates cell cycle via GmACR1

This study identifies a proteolytic processing mechanism of the soybean ethylene receptor GmERS1-1 that modulates cell cycle progression via interaction with GmACR1 and GmCDK7.

Integrative Genetic and Single-Cell Analysis Reveals Macrophages as Key Mediators Linking Aging and Osteoporosis

The paper identifies macrophages as key mediators linking aging and osteoporosis using genetic and single-cell analyses, revealing TGFB1 and HNRNPUL1 as critical regulators.

Hidden genetic diversity in 320 nearly-complete East Asian genome assemblies

The paper presents 320 nearly-complete East Asian genome assemblies, revealing new genetic diversity and structural variations not present in existing global pangenomes.

cGAS bends unpaired DNA to form an unconventional structure that hyperactivates the innate immune response

The paper shows that cGAS hyperactivates in response to unpaired DNA (Bu-DNA) by bending it into a V-shape, revealing a new activation mechanism.

A SIRT5-induced metabolic switch underlies chemoresistance and ATR checkpoint dependence in triple-negative breast cancer

This study identifies SIRT5-induced metabolic changes as a driver of chemoresistance in TNBC and reveals ATR checkpoint dependence as a therapeutic vulnerability.

Non-enzymatic ABHD6 interacts with Akt-FoxO1 axis to regulate selective hepatic insulin resistance

This study identifies a non-enzymatic role of ABHD6 in regulating selective hepatic insulin resistance and MASLD through interaction with the Akt-FoxO1 axis.

Efficient Generation of Humanized Cloned Cattle via Embryonic Stem Cell-Mediated Dual-Round Site-Specific Editing

This study develops a method using bovine epiblast stem cells for efficient gene editing and cloning of cattle, resulting in higher birth and survival rates compared to fibroblast-based cloning.

Understanding Fertility Intention Through the Lens of Family Functioning, Fertility Anxiety and Marriage-Fertility Views: A TPB-Based SEM Approach

This study uses SEM to examine how family functioning, marriage-fertility values, and fertility anxiety influence fertility intentions among newlywed couples in China.

A CRISPR/Cas9-based system using dual-sgRNAs for efficient gene deletion in Mycobacterium abscessus

This paper develops a CRISPR/Cas9 system with dual-sgRNAs for efficient large-fragment gene deletion in Mycobacterium abscessus, achieving over 90% deletion efficiency at certain loci.

A smartphone-based genetically recombinant whole-cell biosensor for highly sensitive monitoring of polychlorinated biphenyls (PCBs)

This paper develops a genetically engineered whole-cell biosensor using E. coli to detect multiple PCB congeners with high sensitivity, and integrates it with a smartphone for real-time monitoring.

Inhibition of Androgen Receptor Exposes Replication Stress Vulnerability in Prostate Cancer

The paper shows that AR inhibition in prostate cancer causes DNA replication stress, which can be exploited by combining with a TLS inhibitor to enhance treatment efficacy.

GWAS of ~30,000 samples with bone mineral density at multiple skeletal sites and its clinical relevance on fracture prediction, genetic correlations and prioritization of drug targets

This study performs GWAS on BMD traits and fracture risk using 30,000 UK Biobank samples, identifies novel loci, and prioritizes drug targets for osteoporosis prevention.

SEAD: an augmented reference panel with 22,134 haplotypes boosts the rare variants imputation and GWAS analysis in Asian population

The paper introduces SEAD, an Asian reference panel that improves rare variant imputation and GWAS analysis, identifying a novel association between SNTG1 and hip BMD.

Detecting Circular RNA from High-throughput Sequence Data with de Bruijn Graph

This paper introduces circDBG, a method for detecting circular RNA using de Bruijn graphs, showing improved accuracy, efficiency, and sensitivity compared to existing methods.

Interplay of Driver, Mini-Driver, and Deleterious Passenger Mutations on Cancer Progression

This paper develops a stochastic model to study how driver, mini-driver, and deleterious passenger mutations influence cancer progression and shows its predictions align with clinical data.

Whole genome analysis of the methylome and hydroxymethylome in normal and malignant lung and liver

The paper analyzes DNA methylation and hydroxymethylation across normal and cancerous lung and liver tissues, revealing their roles in gene expression regulation and differential methylation regions.

Local genetic effects on gene expression across 44 human tissues

This study identifies cis-eQTLs across 44 human tissues using GTEx data, showing 88% of genes have cis-eQTLs and demonstrating their utility in understanding complex trait etiology.

Selection of chromosomal DNA libraries using a multiplex CRISPR system in Saccharomyces cerevisiae

This study develops a CRISPR-based system for efficient chromosomal DNA library selection in yeast, improving cellobiose utilization by ten-fold through targeted mutagenesis.

Expanding xylose metabolism in yeast for plant cell wall conversion to biofuels

This study identifies a xylodextrin transport and consumption pathway in Neurospora crassa and demonstrates its reconstitution in Saccharomyces cerevisiae to enhance plant cell wall sugar utilization for biofuel production.